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Active Ingredient: Paroxetine
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Paxil or Paroxetine

The XXI century can rightfully be considered a century of stress. Each of us is bombarded with a huge amount of information from day to day, and a considerable part of it is very negative. You need to keep dozens or even hundreds of cases in your head, and whole trainings are devoted to time planning and learning how to work with computer programs that can help in this. Life is accelerating — the transmission of information is accelerating, and the amount of stress is also increasing. Up to a certain limit, a person not only successfully copes with them, but also benefits — minor and short-term stress acts like a morning dousing with cold water. However, when such an impact is too strong, the human psyche ceases to cope with it and this becomes the ground for the development of psychosomatic diseases, neuroses, anxiety disorders, depression. That is why the increase in the incidence of neuropsychiatric profile is noted during periods of severe social transformations — wars, international conflicts, global economic crises… But one should not think that such problems are an exceptional burden of modern man — an obsessive fear of death (one of the common anxiety disorders) was described as early as the beginning of the XVII century (Burton E., 1621). However, the good news is that, unlike at that time, today such conditions have learned to treat!

Probably, there is not a single adult today who would be unfamiliar with the concept of anxiety. This is a fear facing the future. And if fear is a normal adaptive reaction of the organism that has arisen in the process of evolution, which is designed to prepare for real danger, then anxiety appears when there is nothing really threatening.

Psychologists explain this state by the fact that the human mind is designed in such a way that it constantly tries to control everything around it, calculate all possible consequences of events in order to protect itself from threats. In the modern world, it is impossible to keep all the information in your head, calculate all the variants of events — the brain is simply overloaded and gives the body a signal of danger, fear, panic.

This is how, seemingly for no apparent reason, a person can develop a panic attack — a sudden and rapidly increasing symptom complex of autonomic disorders (palpitations, chest tightness, feeling of suffocation, lack of air, sweating, dizziness). A person who has experienced a panic attack remembers for a long time those unpleasant moments that he suffered. And this is understandable — imagine that returning from work in the evening you met an angry tiger or bear at the entrance. Your body will react with the release of a huge amount of adrenaline, you will experience a terrible fear that will never be forgotten. During a panic attack, a person feels the same, although there is no real reason for this.

In the future, this leads to the fact that subconsciously a person tries to avoid a situation in which he experienced a panic attack, because there is no other explanation for its cause.

Residents of large cities have such panic attacks most often in the subway, buses, driving a car. This is how various phobias arise — the fear of open (agorophobia) or closed (claustrophobia) spaces, heights (acrophobia), darkness (scotophobia), etc. This is a simplified scheme of the occurrence of anxieties and phobias, the irrational beginning of the human mind sometimes leads to very unusual fears — fear of kissing (philemaphobia), fear of lunch and table conversations (deipnophobia), fear of cats (ailurophobia), fear of the number 13 (triskaidekaphobia) — the list can be continued indefinitely, the fear of which also exists (peyrophobia).

Obsessive rituals also develop on the same principle — in order to avoid an alarming situation, a person washes his hands a hundred times a day, steps on cracks in the asphalt, checks whether the door is closed. This condition is called obsessive-compulsive disorder — it is very painful and brings a lot of suffering.

Anxiety disorders, like all neuroses, also occur with relatively weak, but prolonged and repeatedly acting stimuli, leading to constant emotional tension, internal conflicts, discord with oneself. Contrary to popular opinion, it is precisely such constant and mildly expressed stresses that often lead to the disease, severe psychotrauma causes it much less often.

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Action of Paxil (Paroxetine)

According to epidemiological studies, anxiety disorders are one of the most common forms of mental pathology. Throughout life, anxiety states develop in about 1/4 of the population, and anxiety disorders occur in 11.9% of patients in the general medical network (Sherbourne C.D., 1996).

Very often, disorders begin in adolescence, especially at a time when young people are freed from parental care and plunge into life problems, the solution of which is given to them at the cost of emotional overstrain. Women are more anxious than men. This is due to their genetic characteristics — the level of the chemical with which we suppress the feeling of anxiety is lower in a woman's brain.

According to doctors, patients with anxiety are the last to turn to neurologists, preferring to treat the consequences first, rather than the disease itself, which forces them to visit doctors of almost all specialties with various somatic complaints. At the same time, the symptoms of anxiety disorder are very similar to vegetative-vascular dystonia (VSD), and such a diagnosis is very often made by patients who have experienced a panic attack. Receiving treatment for VSD or somatic pathology, patients do not get rid of anxiety.

Often, following anxiety disorders or in parallel with them, depression develops — one of the most common diseases. According to WHO data, it is expected that by 2020, in terms of morbidity, depression will overtake infectious diseases and diseases of the cardiovascular system and take 2nd place among the 10 main ones leading to disability. Anxiety and depression have common neurochemical roots. They are caused by a decrease in the synthesis and metabolism of neurotransmitters (primarily serotonin) in the brain.

For the treatment of all these conditions, modern drugs belonging to the group of selective serotonin reuptake neuronal inhibitors (SSRIS) are shown, which, moreover, are no less effective at relieving anxiety than most tranquilizers.

One of the brightest representatives of this group is Paroxetine. In the pharmaceutical market, it is presented in the form of a Paxil (manufactured by the Hungarian company Gideon Richter), which has high clinical efficacy and an optimal price and quality ratio. It is not for nothing that the name of this drug contains the root REX (from Lat. rex — king) — which is fully justified by the high efficiency of Paxil.

The mechanism of therapeutic action of Paroxetine is based on inhibition of reverse neuronal capture of serotonin. The chemical structure of Paroxetine differs from tricyclic, tetracyclic and other antidepressants.

Many years of experience in the use of the antidepressant Paxil (Paroxetine) has shown its high anti-anxiety activity in all types of anxiety, even in cases where frequent and intense panic attacks are recorded in the clinical picture. It is also effective in various depressive conditions (endogenous, situational; major depression, dysthymia), including with concomitant anxiety. Another important difference is that Paxil is indicated for various somatic pathologies.

It is also clinically proven that long-term use of Paroxetine does not lead to a significant change in the social activity of patients and does not require professional restrictions.

Treatment with the antidepressant Paxil can be combined with the use of hypotensive, vascular, cardiological, antidiabetic and other drugs, often necessary for patients for vital indications. At the same time, it does not cause addiction or dependence, characteristic of benzodiazepines and barbiturates. However, it should always be remembered that the drug for the treatment of anxiety syndrome is prescribed only by a doctor, and self-medication is dangerous and can worsen the course of the disease.

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